Steroid-induced osteoporosis (SIOP) is osteoporosis arising from the use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involves mainly the axial skeleton. Prescription synthetic glucocorticoid prescription prescription prescription is a major candidate after a long intake. Bisphosphonates are useful in reducing the risk of vertebral fractures. Some professional guidelines recommend supplements of calcium and vitamin D prophylaxis in patients who take more than 30 mg of hydrocortisone (7.5 mg of prednisolone), especially when this is more than three months. The use of thiazid diuretics, and gonadal hormone replacement have also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids are also recommended in refractory cases. Alternative day use can not prevent this complication.
The SIOP mechanism includes:
- Direct inhibition of osteoblast function
- Direct increase of bone resorption
- Inhibition of gastrointestinal calcium absorption
- Increased urinary calcium loss
- Inhibition of sex steroids
Video Steroid-induced osteoporosis
References
Source of the article : Wikipedia
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