Osteocalcin , also known as a protein containing gamma-carboxylic acid bleach ( BGLAP ), is a non-collagen protein found in bones and dentin. Because it has a gla domain, its synthesis depends on vitamin K. In humans, osteocalcin is encoded by the BGLAP gene. The receptor is GPRC6A.
Video Osteocalcin
Function
Osteocalcin is secreted only by the osteoblasts and thought to play a role in the regulation of the body's metabolism and is pro-osteoblastic, or bone formation, naturally. It is also involved in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing the beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases the sensitivity to insulin.
Osteocalcin works on Leydig testis cells to stimulate testosterone biosynthesis and therefore affect male fertility.
Osteocalcin also acts on myocytes to promote energy availability and utilization and in this way supports exercise capacity.
Maps Osteocalcin
Use as biochemical marker for bone formation
Because osteocalcin is produced by osteoblasts, it is often used as a marker for bone formation. It has been observed that higher serum-osteocalcin levels are relatively correlated with increased bone mineral density (BMD) during treatment with anabolic bone formation drugs for osteoporosis, such as Teriparatide. In many studies, osteocalcin is used as an early biomarker on the effectiveness of drugs given to bone formation. For example, a study aimed at studying the effectiveness of a glycoprotein called lactoferrin in bone formation used osteocalcin as a measure of osteoblast activity.
References
Further reading
External links
- Osteocalcin at the US National Library of Medicine Subject Medical Headings (MeSH)
Source of the article : Wikipedia
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