John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (April 17, 1929 - July 13, 2008) is a professor who is at the forefront of clinical immunological techniques, protein biochemistry and bone marrow transplantation, particularly in children's health.
Video John Raymond Hobbs
Kehidupan awal
John Hobbs was born in Aldershot. He is the third son of four sons of a soldier's family. His family moved around because of his father's career in the British Army. The family finally settled in his father's hometown of Plymouth in Devon. During the Second World War, John, along with his three brothers Frederick, William and Dennis, were evacuated from the ravaged Plymouth-wind to Penzance. He left school at the age of 16 and worked as a pathology laboratory assistant and conducted a National Service in Egypt with the British Army Medical Corps. After the National Service, John used the money he saved from the salary of the commanding sergeant to go to Plymouth and Devonport Technical College where he reached the External Inter.B.Sc. in 9 months, got a state scholarship to study medicine, where he chose Middlesex Hospital in London and won 7 prizes. From 1968-1996 Dr. Hobbs received 4 national prizes, 15 international awards, and 4 honorary scholarships
Maps John Raymond Hobbs
Medicine
He specializes in Pathology and in 1963 was appointed as a consultant at Hammersmith Hospital, London. In 1970 he was appointed Professor of Chemical Pathology at Westminster Medical School. In the early 1970s, Professor Hobbs Westminster's team worked hard. In 1970, the world's first successful stem cell transplant for a previously lethal human disease. In 1971, the first British Bone Marrow Transplant used bone marrow from a suitable brother. The following year the transplant successfully used the bone marrow from father to son. In April 1973, Professor Hobbs and his team managed to achieve the world's first bone marrow transplant using a matching but unrelated volunteer donor. With the success of these procedure steps taken by Hobbs professor team to establish the first unrelated bone marrow donor register in the world. The team's network typing specialist, Dr. David James, was instrumental in setting up and administering this ground-breaking register which was later named Anthony Nolan. It establishes the future use of donors unrelated to the patient, so far for more than 10,000 people. This initiative is a blueprint to be copied worldwide. The Westminster team completed 285 transplants before that and its sudden, unpredictable, specialist unit of force was effective in the fall of 1992. Tragically, this leaves the waiting list of children with almost no other place in the UK to go for the treatment of genetic diseases and their luggage. error. But Professor Hobbs has founded the CoRrection of GEnetic diseases through Transplantation or COGENT movement, with a charity trust that attracted Ã, Â £ 13 million from 1971 to 2007. The remainder of the balance, with the help of the late Professor Anthony Oakhill, was used to create a new unit at Royal Hospital for Sick Children in Bristol City, and allow the work to continue. Now headed by Dr. Colin Steward MA (Cantab), BM, BCh (Oxon), PhD (Bristol), FRCPCH, FRCP. As for the children treated by Professor Hobbs' bone marrow team at Westminster Hospital, most of these children now enjoy full life as adults.
Passing Knowledge
Dr Hobbs became an enthusiastic and accomplished teacher and received an invitation to teach (over 30 people) in 58 different countries (in more than half of medical schools in Europe, 25 in the United States and more than 30 Commonwealth universities) professor in more than 25 times and he contributed to many international meetings and committees. He was invited back many times and the President's status was granted to him in five different scientific meetings. He acts as an adviser to the Health Ministers in Russia, Poland, Uruguay, Hong Kong, China, and Peru.
For 30 years as a teacher recognized by Dr. Hobbs encouraging his junior. 134 higher university degrees are attained by trainees for completed work within the department they lead; 48 full university seats have been awarded to the staff; 70 has been a member or member of the Royal College of Pathologists (including 18 non-medical); 12 scientific staff assisted with medical degree; along with 42 students of his contemporaries.
Achievements
- In Protein biochemistry - proven females treated for iron deficiency reaching the normal range of men for hemoglobin blood levels; the pre-existing 'normal' range for women is no longer acceptable.
- From monitoring Myeloma Trials, the first to describe the natural history of myelomatosis and assisted in 1971 to establish a Protein Reference Unit that saved the national health service Ã, Â £ 3 million every year. Dr. John Hobbs retired as PRU chairman in 1994.
- Established the first non-invasive screening test in newborns to detect those affected by cystic fibrosis 1968
- As Chair of the Panel of Experts on Proteins of the International Federation of Clinical Chemists (1971-1979) creates international standards for many serum proteins.
- Develop successful use of human tumor markers
- In Clinical Immunology ,
- Standard methods and reagents (some for WHO) to provide normal ranges from 12 weeks gestation to old age for caucasian populations
- Immunoglobolin levels.
- Responses to candida albicans.
- Complement activation.
- T cell receptor mixed lymphocyte reaction.
- Phagocyte function.
- First to fully describe IgA deficiency.
- Selective deficiency of IgM deficiency to staphylococci.
- Beginning to recognize the subgroup of circulating T-cells that can be co-opted through the Fc receptor to become a kill cell.
- Secondary deficiency of B-cell & gt; and T-cells and their possible treatment can be predicted by cytofluorometry
- In Bone Marrow Transplant she has been taught at the Registrar level, by the late Dr. Joseph G Humble at Westminster Hospital in 1959-61 and is a volunteer donor of his own 500 ml bone marrow (under anesthesia) to be used for research purposes. When he returned in 1970 as head of Chemical Pathology and Immunology, he created the Marrow Bone Westminster Team and led it up to 1992 in his pioneering work to care for 133 children with a deadly genetic disease. The team became so skilled that, out of 56 recent transplants from a suitable family donor, all survived for more than 100 days (criteria for procedure safety). Of unrelated donors, 91% survive for 100 days. In 1992 this result was probably among the best in the world. Improvements in bone marrow transplant introduced by Westminster have been published
- In the Current Content 1972, Dr. John Hobbs is one of 11 UK medical doctors who are on the 'Top 1000 World's best scientists' list.
Family
John Raymond Hobbs is the eldest of four siblings. She is also the father of three daughters and eight grandchildren.
Publications (some 630)
7. Hobbs J.R., Bayliss, R.I.S., MacLagan, N.F. The routine use of 132-I in the diagnosis of thyroid disease (1963) Lancet, i, 8-13. (M.D. Thesis, London)
Hobbs, J. R. Transplantation of bone marrow transplant and immunoprophylaxis for genetic disease. Internal. Med. 33 (1987) 81-118
126 Valdimarrson, J.H., Higgs, J.M., Wells, R.S., Yamamura, M, Hobbs, J.R., Holt, P.J. Immune immunity is associated with chronic mucocutaneous candidiasis, (1973) Cell Immunol. 6, 348-61
144 Ezeoke, A., Ferguson, N, Fakhri, O, Hekkens, W and Hobbs, J.R. Antibodies in celiac patient serum that can co-optate K-cells to attack target labeled gluten (1974) in W Hekkens, U.S. Pen (eds) Celiac Disease, Stenfert Kroese/Leiden, pp 176-188
174 Hobbs, J.R., Barrett, A, de Souza, I., Morgan, L., Raggatt, P., Salih, H., Selection of anti-hormonal therapy of some cancers (1975) in D Minzuni et al. (eds) Host Defense Against Cancer and Its Potential, Univ from Tokyo Press, Tokyo/Univ. Park Press/Baltimore, pp 451-6
204 Hobbs J.R., Encouragement of research on cancer of individual patients (1977) in R.W. Raven, The View of Cancer, Plenum/London, pp 147-162
319 Hobbs J.R., AIDS (1984) huruf B.J. Hosp. Med. 32:51
448 Hobbs J.R., Use of unrelated volunteer donors in J R Hobbs (ed) Correction of specific genetic diseases with transplantation, 1989, COGENT/London 1989: 147-158
484 Henderson D.C., Sheldon J., Riches P.G., Hobbs J.R. Induksi sitokin dari produksi neopterin, Clin Exp Immunol 1991; 83: 479-482
497 Wang Q., Rowbottom A., Riches P.G., Dadian G., Hobbs J.R. Combined detection of phenotypes and Y chromosomes by immunoenzymelabelling and in situ hybridisatin in peripheral lymphocytes, J Immunol Methods 1991; 139: 251-5
547 Hobbs J.R., Wang Q., Henderson D.C., Downie C., Obaro S., Induction Busulphan-cyclophosphamide was used twice with 9/12 success in second bone marrow transplant, COGENT 1992; 2: 127-135
630 Hobbs J.R., A further aspect of immune human immunoglobulin A deficiency, Ann Clin Biochem 2007; 44: 496-7
References
References Compiled and modified with the help of J R Hobbs.
See also
- Brother John, Canadian artist William G. Hobbs.
Source of the article : Wikipedia
0 Comments