Lymphocyte donor ( or leukocyte ) infusion (DLI) or buffy coat injection is a form of adoption immunotherapy used after hematopoietic stem cell transplantation.
Video Donor lymphocyte infusion
History
Previously, the only treatment option that offers patients with recurrent bone marrow transplantation who wish to recover is bone marrow transplantation. However, the risk of serious life-threatening complications after a second BMT is very good. One strategy for managing relapse, donor leukocyte infusion, may eliminate the need for a second BMT in some patients.
Maps Donor lymphocyte infusion
Procedures
Infusion lymphocyte donors are infusions in which lymphocytes from the original stem cell donors are infused, after transplantation, to supplement an anti-tumor immune response or to ensure that donor stem cells remain stranded. These donated white blood cells contain immune system cells that can recognize and destroy cancer cells.
The aim of this therapy is to encourage patient's forgiveness by a process called the graft-versus-tumor effect (GVT). T donor cells can attack and control the growth of residual cancer cells that give GVT effect. Expected donor leukocyte infusion will cause GVT and lead to patient's cancer forgiveness.
Patients may require standard chemotherapy, to reduce the number of cancer cells they have before their donor lymphocyte infusion.
Complications
DLI complications include acute and chronic graft-versus-host disease and bone marrow aplasia, resulting in immunosuppression and susceptibility to opportunistic infections.
References
Further reading
- Thomas Hematopoietic Cell Transplant, ed. Blume KG, Forman SJ, Appelbaum FR. Publisher Blackwell, Cambridge, MA: 2004. ISBNÃ, 1-4051-1256-5.
Source of the article : Wikipedia
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